You should start here:
http://nsis.sourceforge.net/Docs/Chapter4.html#4.9.2
Maybe try like this:
code:
ReadRegStr $0 HKCU "Environment" "Path" #read current PATH into $0
StrCpy $0 "C:\SomePath;$0" #prepend your path to the current PATH value
WriteRegStr HKCU "Environment" "Path" '$0' #write back the new PATH
(Note that the new PATH may become effective only after a reboot)