Is the 'General Preferences - File Types - Shell Options - Start Winamp playing if it is not already' option checked?
Are you using the same version of Firefox as before? Some stuff was changed in the latest version for security concerns. The option to 'download and open' could now be separated to download, then open. I suggest you post the question on the Firefox forum.
I've never used 'download and open' because I want to check the downloads for virus and/or malware before I open them.
Winamp Pro 5.666.3516 fully-patched - Komodo X Touchscreen by Victhor skin
Windows 10 Home 64-bit desktop - Logitech Z906 5.1 speaker system