Responsive design is doable, in the sense of locate /place content according to the available space. But not even a simple / "fixed gfx" skin is easy to do.. So, no, there is no straight path from a PSD to turn it into a Winamp skin. For that, you'll be better off with Xion (http://www.xionplayer.com
I made the skin you're recommended to use (Komodo X), have you tried it? I'm actively developing skins and improving that one specifically. So I'm looking for some feedback of actual users, specially if they're not advanced Winamp users. Please stop by the skin's thread (http://forums.winamp.com/showthread.php?t=388090
) if you have any suggestions for the skin or have issues using it.