first, you can do everything with nsis.
second, the installer is able to delete itself while running
third, a 100% copy protection is not available on any computer system, since there are always abilities to crack them.
delete the exec may be worked around by restore it with restoring tools or simply by start it write-protected.
key in registry or any file entry may be worked around by delete it.
software can't be copy protected 100%
but every 99% trick is doable with nsis.