oops must have missed this on the first time around. I though that smoke had all changed on 1.04beta1 as you now have the target fps. Idiot, I hope you do not have this as low as it can go.
LOL It goes down to 2. What is the point of that?
It is recommended you have a decent-ish processor 800Mhz+ but I would have target fps would be just keep decreasing the mesh size until you get there.
Idiot running it at a target fps of 60fps what fps do you get?